 |
 |
 |
 |
 |
|
neuropharmacology and behaviourSelected PublicationsMARCOS B, AISA B, CHUANG TT, GIL-BEA FJ, RAMÍREZ MJ. Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. Synapse. 2009 Sep;63(9):814-6. ABSTRACT COURTESY OF PUBMEDGARCIA-GARCIA AL, ELIZALDE N, MATROV D, HARRO J, WOJCIK SM, VENZALA E, RAMÍREZ MJ, DEL RIO J, TORDERA RM. Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. Biol Psychiatry. 2009 Aug 1;66(3):275-82.
ABSTRACT COURTESY OF PUBMEDSIMÓN AM, DE MATURANA RL, RICOBARAZA A, ESCRIBANO L, SCHIAPPARELLI L, CUADRADO-TEJEDOR M, PÉREZ-MEDIAVILLA A, AVILA J, DEL RÍO J, FRECHILLA D. Early Changes in Hippocampal Eph Receptors Precede the Onset of Memory Decline in Mouse Models of Alzheimer's Disease. J Alzheimers Dis. 2009 Jun 19. ABSTRACT COURTESY OF PUBMEDRICOBARAZA A, CUADRADO-TEJEDOR M, PÉREZ-MEDIAVILLA A, FRECHILLA D, DEL RÍO J, GARCÍA-OSTA A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology. 2009 Jun;34(7):1721-32.
ABSTRACT COURTESY OF PUBMEDBURGOS-RAMOS E, MARTOS-MORENO GA, LÓPEZ MG, HERRANZ R, AGUADO-LLERA D, EGEA J, FRECHILLA D, CENARRUZABEITIA E, LEÓN R, ARILLA-FERREIRO E, ARGENTE J, BARRIOS V. The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation. J Neurochem. 2009 Apr;109(2):360-70.
ABSTRACT COURTESY OF PUBMEDSIMÓN AM, SCHIAPPARELLI L, SALAZAR-COLOCHO P, CUADRADO-TEJEDOR M, ESCRIBANO L, LÓPEZ DE MATURANA R, DEL RÍO J, PÉREZ-MEDIAVILLA A, FRECHILLA D. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Neurobiol Dis. 2009 Mar;33(3):369-78.
ABSTRACT COURTESY OF PUBMEDESCRIBANO L, SIMÓN AM, PÉREZ-MEDIAVILLA A, SALAZAR-COLOCHO P, DEL RÍO J, FRECHILLA D. Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model. Biochem Biophys Res Commun. 2009 Feb 6;379(2):406-10. ABSTRACT COURTESY OF PUBMEDBECERRA SP, PEREZ-MEDIAVILLA LA, WELDON JE, LOCATELLI-HOOPS S, SENANAYAKE P, NOTARI L, NOTARIO V, HOLLYFIELD JG. Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. J Biol Chem. 2008 Nov 28;283(48):33310-20. ABSTRACT COURTESY OF PUBMEDSALAZAR-COLOCHO P, DEL RÍO J, FRECHILLA D. Involvement of the vascular wall in regenerative processes after CA1 ischemic neuronal death. Int J Dev Neurosci. 2008 Oct;26(6):541-50. ABSTRACT COURTESY OF PUBMEDMARCOS B, CHUANG TT, GIL-BEA FJ, RAMIREZ MJ. Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br J Pharmacol. 2008 Oct;155(3):434-40. ABSTRACT COURTESY OF PUBMEDAISA B, TORDERA R, LASHERAS B, DEL RÍO J, RAMÍREZ MJ. Effects of maternal separation on hypothalamic-pituitary-adrenal responses, cognition and vulnerability to stress in adult female rats. Neuroscience. 2008 Jul 17;154(4):1218-26.
ABSTRACT COURTESY OF PUBMEDSALAZAR-COLOCHO P, LANCIEGO JL, DEL RIO J, FRECHILLA D. Ischemia induces cell proliferation and neurogenesis in the gerbil hippocampus in response to neuronal death. Neurosci Res. 2008 May;61(1):27-37.
ABSTRACT COURTESY OF PUBMEDGOÑI-ALLO B, PUERTA E, MATHÚNA BO, HERVIAS I, LASHERAS B, DE LA TORRE R, AGUIRRE N. On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. Neuropharmacology. 2008 Apr;54(5):885-900.
ABSTRACT COURTESY OF PUBMEDMARCOS B, AISA B, RAMÍREZ MJ. Functional interaction between 5-HT(6) receptors and hypothalamic-pituitary-adrenal axis: cognitive implications. Neuropharmacology. 2008 Mar;54(4):708-14. ABSTRACT COURTESY OF PUBMEDPÉREZ DE VEGA MJ, BAEZA JL, GARCÍA-LÓPEZ MT, VILA-PERELLÓ M, JIMÉNEZ-CASTELLS C, SIMÓN AM, FRECHILLA D, DEL RÍO J, GUTIÉRREZ-GALLEGO R, ANDREU D, GONZÁLEZ-MUÑIZ R. Synthesis and biological properties of beta-turned Abeta (31-35) constrained analogues. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2078-82. ABSTRACT COURTESY OF PUBMEDSALAZAR-COLOCHO P, DEL RÍO J, FRECHILLA D. Neuroprotective effects of serotonin 5-HT(1A) receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF. Brain Res. 2008 Feb 11 [Epub ahead of print] ABSTRACT COURTESY OF PUBMEDGOÑI-ALLO B, PUERTA E, RAMOS M, LASHERAS B, JORDÁN J, AGUIRRE N. Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK. J Neurochem. 2008 Feb;104(4):914-25. ABSTRACT COURTESY OF PUBMEDGONI-ALLO B, O MATHÚNA B, SEGURA M, PUERTA E, LASHERAS B, DE LA TORRE R, AGUIRRE N. The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity. Psychopharmacology (Berl). 2007 Dec 12. ABSTRACT COURTESY OF PUBMEDSALAZAR-COLOCHO P, DEL RÍO J, FRECHILLA D. Serotonin 5-hT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia. J Physiol Biochem. 2007 Sep;63(3):203-11. ABSTRACT COURTESY OF PUBMEDJORDAN J, FERNANDEZ-GOMEZ FJ, RAMOS M, IKUTA I, AGUIRRE N, GALINDO MF. Minocycline and cytoprotection: shedding new light on a shadowy controversy.Curr Drug Deliv. 2007 Jul;4(3):225-31. ABSTRACT COURTESY OF PUBMEDGOÑI-ALLO B, PUERTA E, HERVÍAS I, DI PALMA R, RAMOS M, LASHERAS B, AGUIRRE N. Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats. Eur J Pharmacol. 2007 May 21;562(3):198-207. ABSTRACT COURTESY OF PUBMEDGIL-BEA FJ, AISA B, SCHLIEBS R, RAMIREZ MJ. Increase of locomotor ativity underlying the behavioral disinhibition in Tg2576 mice. Behav Neurosci. 2007 Apr;121(2):340-4. ABSTRACT COURTESY OF PUBMEDAISA B, TORDERA R, LASHERAS B, DEL RÍO J, RAMÍREZ MJ. Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 2007 Apr;32(3):256-66. Epub 2007 Feb 20. ABSTRACT COURTESY OF PUBMEDMARTÍNEZ-TURRILLAS R, DEL RÍO J, FRECHILLA D. Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs.Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. GARCIA-ALLOZA M, ZALDUA N, DIEZ-ARIZA M, MARCOS B, LASHERAS B, JAVIER GIL-BEA F, RAMIREZ MJ. Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol. 2006 Nov;65(11):1074-81. ABSTRACT COURTESY OF PUBMEDGARCIA-ALLOZA M, TSANG SW, GIL-BEA FJ, FRANCIS PT, LAI MK, MARCOS B, CHEN CP, RAMIREZ MJ. Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. Neurobiol Aging. 2006 Aug;27(8):1110-7. ABSTRACT COURTESY OF PUBMEDALONSO DE DIEGO S, GUTIÉRREZ-RODRÍGUEZ M, PÉREZ DE VEGA M, GONZÁLEZ-MUÑIZ R, HERRANZ R, MARTÍN-MARTINES M, CENARRUZABEITIA E, FRECHILLA D, DEL RIO J, JIMERO M, GARCÍA-LÓPEZ M. The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett 2006 Jul 1;16(13):3396-400. ABSTRACT COURTESY OF PUBMEDMARTÍNEZ-TURRILLAS R, MOYANO S, DEL RIO J, FRECHILLA D. Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on BDNF mRNA expression in rat frontal cortex and hippocampus. Neurosci Lett. 2006 Jul 10;402(1-2):126-30. ABSTRACT COURTESY OF PUBMEDSCHIAPPARELLI L, SIMÓN A, DEL RÍO J, FRECHILLA D. Opposing effects of AMPA and 5-ht1a receptor blockade on passive avoidance and object recognition performance: correlation with ampa receptor subunit expression in rat hippocampus. Neuropharmacology 2006 Jun;50(7):897-907. Epub 2006 Apr 18. ABSTRACT COURTESY OF PUBMEDLAI MK, TSANG SW, GARCIA-ALLOZA M, MINGER SL, NICOLL JA, ESIRI MM, WONG PT, CHEN CP, RAMÍREZ MJ, FRANCIS PT. Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. Neurobiol Dis. 2006 Jun;22(3):555-61. ABSTRACT COURTESY OF PUBMEDNIETO M, GIL-BEA FJ, DALFÓ E, CUADRADO M, CABODEVILLA F, SÁNCHEZ B, CATENA S, SESMA T, RIBÉ E, FERRER I, RAMÍREZ MJ, GÓMEZ-ISLA T. Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiol Aging. 2006 Jun;27(6):848-56. ABSTRACT COURTESY OF PUBMEDGOÑI-ALTO B, RAMOS M, HERVÍAS I, LASHERAS B, AGUIRRE N. Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/malonate combination: implications for serotonin/dopamine interactions. J Psychofarmacol. 2006 Mar;20(2):245-56. ABSTRACT COURTESY OF PUBMEDALONSO DE DIEGO S, GUTIÉRREZ-RODRÍGUEZ M, PÉREZ DE VEGA M, CASABONA D, CATIVIELA C, GONZÁLEZ-MUÑIZ R, HERRANZ R, CENARRUZABEITIA E, FRECHILLA D, DEL RÍO J, GARCÍA-LÓPEZ M, JIMENO M. New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. ABSTRACT COURTESY OF PUBMEDRIBÉ EM, PÉREZ M, PUIG B, GICH I, LIM F, CUADRADO M, SESMA T, CATENA S, SÁNCHEZ B, NIETO M, GÓMEZ-RAMOS P, MORÁN MA, CABODEVILLA F, SAMARANCH L, ORTIZ L, PÉREZ A, FERRER I, AVILA J, GÓMEZ-ISLA T. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiol Dis. 2005 Dec;20(3):814-22. ABSTRACT COURTESY OF PUBMEDMOYANO S, DEL RIO J, FRECHILLA D. Acute and chronic effects of MDMA on molecular mechanisms implicated in memeoy formation in rat hipocampus: Surface expression of CaMKII and NMDA receptor subunits. Pharmacol. Biochem. Behav. 2005 Sep;82(1):190-9. ABSTRACT COURTESY OF PUBMEDSCHIAPPARELLI L, DEL RIO J, FRECHILLA D. Serotonin 5-HT1A receptor blockade enhances Ca2+/calmodulin-dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus. J. Neurochem. 2005 Aug;94(4):884-95. ABSTRACT COURTESY OF PUBMEDGIL-BEA FJ, GARCÍA-ALLOZA M, DOMÍNGUEZ J, MARCOS B, RAMÍREZ MJ. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neurosci Lett. 2005 Feb 25;375(1):37-41. ABSTRACT COURTESY OF PUBMEDBARANZINI E, MOUSAVI P, DEL RIO J, CAILLIER S, STILLMAN S, VILLOSLADA P, WYATT M, COMABELLA M, GRELLER L, SOMOGYI R, MONTALBÁN X, OKSENBERG J. Transcription-based prediction of response to IFNbeta using supervised computational methods. PLoS Biol. 2005 Jan;3(1):e2. ABSTRACT COURTESY OF PUBMEDGARCIA-ALLOZA M, GIL-BEA FJ, DIEZ-ARIZA M, CHEN CP, FRANCIS PT, LASHERAS B, RAMIREZ MJ. Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. Neuropsychologia. 2005;43(3):442-9. ABSTRACT COURTESY OF PUBMEDMOYANO S, DEL RIO J, FRECHILLA D. Role of hippocampal CaMKII in serotonin 5-HT(1A) receptor-mediated learning deficit in rats. Neuropsychopharmacology 2004 Dec;29(12):2216-24. ABSTRACT COURTESY OF PUBMEDPUIG B, GÓMEZ-ISLA T, RIBE E, CUADRADO M, TORREJÓN-ESCRIBANO B, DALFO E, FERRER I. Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JKN-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP tg2576 mice. Neuropathol Appl Neurobiol. 2004 Oct;30(5):491-502. ABSTRACT COURTESY OF PUBMEDMOYANO S, FRECHILLA D, DEL RIO J NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment. Psychopharmacology 2004 May;173(3-4):337-45. Epub 2004 Feb 25. ABSTRACT COURTESY OF PUBMEDGARCIA-ALLOZA M, HIRST WD, CHEN CP, LASHERAS B, FRANCIS PT, RAMÍREZ MJ. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology. 2004 Feb;29(2):410-6. ODRIOZOLA L, CRUCHAGA C, ANDRÉOLA M, DOLLÉ V, NGUYEN CH, TARRAGO-LITVAK L, PÉREZ-MEDIAVILLA A, MARTÍNEZ-IRUJO JJ. Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate. J Biol Chem. 2003 Oct 24;278(43):42710-6. Epub 2003 Aug 13. ABSTRACT COURTESY OF PUBMEDWANG L, SCHMITZ V, PEREZ-MEDIAVILLA A, IZAL I, PRIETO J, QIAN C. Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor. Mol Ther. 2003 Jul;8(1):72-9. ABSTRACT COURTESY OF PUBMEDWU AS, KIAEI M, AGUIRRE N, CROW JP, CALINGASAN NY, BROWNE SE, BEAL MF. Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. J Neurochem. 2003 Apr;85(1):142-50. ABSTRACT COURTESY OF PUBMEDVILLOSLADA P, BARCELLOS LF, DEL RIO J, BEGOVICH AB, TINTORE M, SASTRE-GARRIGA J, CASQUERO P, HAUSER SL, MONTALBAN X, OKSENBERG JR. The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon beta. J Neuroimmunol 2002 Sep;130:194-201
ABSTRACT COURTESY OF PUBMED |
|
|