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CIMA Oncology Neurosciences Cardiovascular sciences Gene therapy & Hepatology division

immunology of viral hepatitis



Selected Publications


LLOPIZ D, DOTOR J, CASARES N, BEZUNARTEA J, DÍAZ-VALDÉS N, RUIZ M, ARANDA F, BERRAONDO P, PRIETO J, LASARTE JJ, BORRÁS-CUESTA F, SAROBE P.

Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy. Int J Cancer. 2009 Dec 1;125(11):2614-23.
ABSTRACT COURTESY OF PUBMED

MANSILLA C, GORRAIZ M, MARTINEZ M, CASARES N, ARRIBILLAGA L, RUDILLA F, ECHEVERRIA I, RIEZU-BOJ JI, SAROBE P, BORRÁS-CUESTA F, PRIETO J, LASARTE JJ.

Immunization against hepatitis C virus with a fusion protein containing the extra domain A from fibronectin and the hepatitis C virus NS3 protein. J Hepatol. 2009 Sep;51(3):520-7. Epub 2009 Jun 23.
ABSTRACT COURTESY OF PUBMED

GIL-GUERRERO L, DOTOR J, HUIBREGTSE IL, CASARES N, LÓPEZ-VÁZQUEZ AB, RUDILLA F, RIEZU-BOJ JI, LÓPEZ-SAGASETA J, HERMIDA J, VAN DEVENTER S, BEZUNARTEA J, LLOPIZ D, SAROBE P, PRIETO J, BORRÁS-CUESTA F, LASARTE JJ.

In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1. J Immunol. 2008 Jul 1;181(1):126-35.
ABSTRACT COURTESY OF PUBMED

DURANTEZ M, LOPEZ-VAZQUEZ AB, DE CERIO AL, HUARTE E, CASARES N, PRIETO J, BORRAS-CUESTA F, LASARTE JJ, SAROBE P

Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes, Scand J Immunol 2009 Feb;69(2):80-9. Epub 2008 Dec 10.
ABSTRACT COURTESY OF PUBMED

ZABALA M, LASARTE JJ, PERRET C, SOLA J, BERRAONDO P, ALFARO M, LARREA E, PRIETO J, KRAMER MG.

Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer. J Hepatol. 2007 Dec;47(6):807-15. Epub 2007 Oct 1.
ABSTRACT COURTESY OF PUBMED

DOTOR J, LÓPEZ-VÁZQUEZ AB, LASARTE JJ, SAROBE P, GARCÍA-GRANERO M, RIEZU-BOJ JI, MARTÍNEZ A, FEIJOÓ E, LÓPEZ-SAGASETA J, HERMIDA J, PRIETO J, BORRÁS-CUESTA F.

Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library. Cytokine. 2007 Aug;39(2):106-15. Epub 2007 Sep 4
   
   
ABSTRACT COURTESY OF PUBMED

ROLLIER CS, PARANHOS-BACCALA G, VERSCHOOR EJ, VERSTREPEN BE, DREXHAGE JA, FAGROUCH Z, BERLAND JL, KOMURIAN-PRADEL F, DUVERGER B, HIMOUDI N, STAIB C, MEYR M, WHELAN M, WHELAN JA, ADAMS VC, LARREA E, RIEZU JI, LASARTE JJ, BARTOSCH B, COSSET FL, SPAAN WJ, DIEPOLDER HM, PAPE GR, SUTTER G, INCHAUSPE G, HEENEY JL.

Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology. 2007 Mar;45(3):602-13
   
ABSTRACT COURTESY OF PUBMED

LASARTE JJ, CASARES N, GORRAIZ M, HERVÁS-STUBBS S, ARRIBILLAGA L, MANSILLA C, DURANTEZ M, LLOPIZ D, SAROBE P, BORRÁS-CUESTA F, PRIETO J, LECLERC C.

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo. J Immunol. 2007 Jan 15;178(2):748-56.
ABSTRACT COURTESY OF PUBMED

LARREA E, RIEZU-BOJ JI, GIL-GUERRERO L, CASARES N, ALDABE R, SAROBE P, CIVEIRA MP, HEENEY JL, ROLLIER C, VERSTREPEN B, WAKITA T, BORRÁS-CUESTA F, LASARTE JJ, PRIETO J

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol. 2007 Apr;81(7):3662-6. Epub 2007 Jan 17
ABSTRACT COURTESY OF PUBMED

ARRIBILLAGA L, SAROBE P, ARINA A, GORRAIZ M, BORRÁS-CUESTA F, RUIZ J, PRIETO J, CHEN L, MELERO I, LASARTE JJ.

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine. 2005 May 20;23(27):3493-9.
ABSTRACT COURTESY OF PUBMED

CASARES N, ARRIBILLAGA L, SAROBE P, DOTOR J, LOPEZ-DIAZ DE CERIO A, MELERO I, PRIETO J, BORRÁS-CUESTA F, LASARTE JJ

CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. J Immunol. 2003 Dec 1;171(11):5931-9.
ABSTRACT COURTESY OF PUBMED


gene therapy and hepatology
lines & labs

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