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gene therapy in immunologySelected PublicationsMURILLO O, DUBROT J, PALAZÓN A, ARINA A, AZPILIKUETA A, ALFARO C, SOLANO S, OCHOA MC, BERASAIN C, GABARI I, PÉREZ-GRACIA JL, BERRAONDO P, HERVÁS-STUBBS S, MELERO I. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol. 2009 Sep;39(9):2424-36 ALFARO C, SUAREZ N, GONZALEZ A, SOLANO S, ERRO L, DUBROT J, PALAZON A, HERVAS-STUBBS S, GURPIDE A, LOPEZ-PICAZO JM, GRANDE-PULIDO E, MELERO I, PEREZ-GRACIA JL. Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes. Br J Cancer. 2009 Apr 7;100(7):1111-9. Epub 2009 Mar 10 MELERO I, MARTINEZ-FORERO I, DUBROT J, SUAREZ N, PALAZÓN A, CHEN L. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.Clin Cancer Res. 2009 Mar 1;15(5):1507-9. Epub 2009 Feb 24. Comment on: MURILLO O, ARINA A, HERVAS-STUBBS S, GUPTA A, MCCLUSKEY B, DUBROT J, PALAZÓN A, AZPILIKUETA A, OCHOA MC, ALFARO C, SOLANO S, PÉREZ-GRACIA JL, OYAJOBI BO, MELERO I. Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma.Clin Cancer Res. 2008 Nov 1;14(21):6895-906. ABSTRACT COURTESY OF PUBMEDMELERO I, MURILLO O, DUBROT J, HERVÁS-STUBBS S, PEREZ-GRACIA JL. Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.Trends Pharmacol Sci. 2008 Aug;29(8):383-90. Epub 2008 Jul 1. ABSTRACT COURTESY OF PUBMEDARINA A, MURILLO O, DUBROT J, AZPILIKUETA A, GABARI I, PEREZ-GRACIA JL, ALFARO C, BERASAIN C, PRIETO J, FERRINI S, HERVAS-STUBBS S, MELERO I. Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. Gene Ther. 2008 Apr;15(7):473-83. Epub 2008 Feb 14. ABSTRACT COURTESY OF PUBMEDMAZZOLINI G, MURILLO O, ATORRASAGASTI C, DUBROT J, TIRAPU I, RIZZO M, ARINA A, ALFARO C, AZPILICUETA A, BERASAIN C, PEREZ-GRACIA JL, GONZALEZ A, MELERO I. Immunotherapy and immunoescape in colorectal cancer. World J Gastroenterol. 2007 Nov 28;13(44):5822-31. ABSTRACT COURTESY OF PUBMEDARINA A, MURILLO O, HERVÁS-STUBBS S, AZPILIKUETA A, DUBROT J, TIRAPU I, HUARTE E, ALFARO C, PÉREZ-GRACIA JL, GONZÁLEZ-ASEGUINOLAZA G, SAROBE P, LASARTE JJ, JAMIESON A, PRIETO J, RAULET DH, MELERO I. The combined actions of NK and T lymphocytes are necessary to reject an
EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN
gamma. Int J Cancer. 2007 Sep 15;121(6):1282-95. ABSTRACT COURTESY OF PUBMEDREDONDO P, DEL OLMO J, LÓPEZ-DIAZ DE CERIO A, INOGES S, MARQUINA M, MELERO I, BENDANDI M. Imiquimod enhances the systemic immunity attained by local cryosurgery destruction of melanoma lesions. J Invest Dermatol. 2007 Jul;127(7):1673-80. Epub 2007 Mar 22. ABSTRACT COURTESY OF PUBMEDMELERO I, HERVAS-STUBBS S, GLENNIE M, PARDOLL DM, CHEN L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer. 2007 Feb;7(2):95-106. ABSTRACT COURTESY OF PUBMEDALFARO C, MURILLO O, TIRAPU I, AZPILICUETA A, HUARTE E, ARINA A, ARRIBILLAGA L, PÉREZ-GRACIA JL, BENDANDI M, PRIETO J, LASARTE JJ, MELERO I. The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases. An Sist Sanit Navar. 2006 Jan-Apr;29(1):77-96. ABSTRACT COURTESY OF PUBMEDMELERO I, ARINA A, MURILLO O, DUBROT J, ALFARO C, PÉREZ-GRACIA JL, BENDANDI M, HERVÁS-STUBBS S. Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena. Clin Cancer Res. 2006 Apr 15;12(8):2385-9. ABSTRACT COURTESY OF PUBMEDHUARTE E, LARREA E, HERNÁNDEZ-ALCOCEBA R, ALFARO C, MURILLO O, ARINA A, TIRAPU I, AZPILICUETA A, HERVÁS-STUBBS S, BORTOLANZA S, PÉREZ-GRACIA JL, CIVEIRA MP, PRIETO J, RIEZU-BOJ JI, MELERO I. Recombinant adenoviral vectors turn on the type I interferon system
without inhibition of transgene expression and viral replication. Mol Ther. 2006 Jul;14(1):129-38. Epub 2006 Apr 19. ABSTRACT COURTESY OF PUBMEDTIRAPU I, HUARTE E, GUIDUCCI C, ARINA A, ZARATIEGUI M, MURILLO O, GONZALEZ A, BERASAIN C, BERRAONDO P, FORTES P, PRIETO J, COLOMBO MP, CHEN L, MELERO I. Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Res. 2006 Feb 15;66(4):2442-50. ABSTRACT COURTESY OF PUBMEDSANGRO B, MELERO I, QIAN C, PRIETO J. Gene therapy of cancer based on interleukin 12. Curr Gene Ther. 2005 Dec;5(6):573-81. ABSTRACT COURTESY OF PUBMEDMELERO I, ARINA A, CHEN L. The many sounds of T lymphocyte silence. Immunol Res. 2005;33(2):135-47. ABSTRACT COURTESY OF PUBMEDFEIJOÓ E, ALFARO C, MAZZOLINI G, SERRA P, PEŃUELAS I, ARINA A, HUARTE E, TIRAPU I, PALENCIA B, MURILLO O, RUIZ J, SANGRO B, RICHTER JA, PRIETO J, MELERO I. Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8. Int J Cancer. 2005 Aug 20;116(2):275-81. ABSTRACT COURTESY OF PUBMEDHUARTE E, TIRAPU I, ARINA A, VERA M, ALFARO C, MURILLO O, PALENCIA B, BUSTO V, MARÍN V, MAZZOLINI G, MELERO I. Intratumoural administration of dendritic cells: hostile environment and help by gene therapy. Expert Opin Biol Ther. 2005 Jan;5(1):7-22. ABSTRACT COURTESY OF PUBMEDMAZZOLINI G, ALFARO C, SANGRO B, FEIJOÓ E, RUIZ J, BENITO A, TIRAPU I, ARINA A, SOLA J, HERRAIZ M, LUCENA F, OLAGÜE C, SUBTIL J, QUIROGA J, HERRERO I, SÁDABA B, BENDANDI M, QIAN C, PRIETO J, MELERO I. Intratumoral injection of dendritic cells engineered to secrete
interleukin-12 by recombinant adenovirus in patients with metastatic
gastrointestinal carcinomas. J Clin Oncol. 2005 Feb 10;23(5):999-1010. Epub 2004 Dec 14. ABSTRACT COURTESY OF PUBMEDRODRÍGUEZ CALVILLO M, INOGÉS S, LÓPEZ DÍAZ DE CERIO A, ZABALEGUI N, PANIZO C, HERNÁNDEZ M, PÉREZ CALVO J, PRÓSPER F, MELERO I, SÁNCHEZ-IBARROLA A, ROCHA E, BENDANDI M. Past, present and future of anti-idiotype vaccination. Rev Med Univ Navarra. 2004 Jul-Sep;48(3):14-23. ABSTRACT COURTESY OF PUBMEDTIRAPU I, ARINA A, MAZZOLINI G, DUARTE M, ALFARO C, FEIJOO E, QIAN C, CHEN L, PRIETO J, MELERO I. Improving efficacy of interleukin-12-transfected dendritic cells
injected into murine colon cancer with anti-CD137 monoclonal antibodies
and alloantigens. Int J Cancer. 2004 May 20;110(1):51-60. ABSTRACT COURTESY OF PUBMEDSANGRO B, MAZZOLINI G, RUIZ J, HERRAIZ M, QUIROGA J, HERRERO I, BENITO A, LARRACHE J, PUEYO J, SUBTIL JC, OLAGÜE C, SOLA J, SÁDABA B, LACASA C, MELERO I, QIAN C, PRIETO J. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol. 2004 Apr 15;22(8):1389-97. ABSTRACT COURTESY OF PUBMEDPRIETO J, QIAN C, SANGRO B, MELERO I, MAZZOLINI G. Biologic therapy of liver tumors. Surg Clin North Am. 2004 Apr;84(2):673-96. ABSTRACT COURTESY OF PUBMEDSAROBE P, FEIJOÓ E, ALFARO C, MAZZOLINI G, MELERO I. MAGE antigens: therapeutic targets in hepatocellular carcinoma? J Hepatol. 2004 Jan;40(1):155-8. ABSTRACT COURTESY OF PUBMEDINOGÉS S, RODRÍGUEZ CALVILLO M, LÓPEZ DÍAZ DE CERIO A, ZABALEGUI N, MELERO I, SÁNCHEZ IBARROLA A, ROCHA E, BENDANDI M. Active immunotherapy in the treatment of haematological neoplasias. An Sist Sanit Navar. 2004 Jan-Apr;27(1):45-62. ABSTRACT COURTESY OF PUBMEDMAZZOLINI G, MELERO I, PRIETO J. Role of interleukin-12 in cancer immunotherapy. Medicina (B Aires). 2004;64(1):77-8. ABSTRACT COURTESY OF PUBMED |
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