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clinical immunologySelected PublicationsLIU J, HUANGFU WC, KUMAR KG, QIAN J, CASEY JP, HAMANAKA RB, GRIGORIADOU C, ALDABE R, DIEHL JA, FUCHS SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe. 2009 Jan 22;5(1):72-83. ABSTRACT COURTESY OF PUBMEDLARREA E, ALDABE R, GONZALEZ I, SEGURA V, SAROBE P, ECHEVERRIA I, PRIETO J. Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells. J Virol. 2009 Apr;83(7):3298-311. Epub 2009 Jan 21. ABSTRACT COURTESY OF PUBMEDAMETZAZURRA A, GÁZQUEZ C, LASA M, LARREA E, PRIETO J, ALDABE R Characterization of the human Nalpha-terminal acetyltransferase B enzymatic complex. BMC Proc. 2009 Aug 4;3 Suppl 6:S4 ABSTRACT COURTESY OF PUBMEDBENEDICTO I, MOLINA-JIMÉNEZ F, BARTOSCH B, COSSET FL, LAVILLETTE D, PRIETO J, MORENO-OTERO R, VALENZUELA-FERNÁNDEZ A, ALDABE R, LÓPEZ-CABRERA M, MAJANO PL The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol. 2009 Aug;83(16):8012-20 ABSTRACT COURTESY OF PUBMEDAMETZAZURRA A, LARREA E, CIVEIRA MP, PRIETO J, ALDABE R. Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. Oncogene. 2008 Dec 11;27(58):7296-306. Epub 2008 Sep 15. ABSTRACT COURTESY OF PUBMEDBENEDICTO I, MOLINA-JIMÉNEZ F, BARREIRO O, MALDONADO-RODRÍGUEZ A, PRIETO J, MORENO-OTERO R, ALDABE R, LÓPEZ-CABRERA M, MAJANO PL. Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum. Hepatology. 2008 Oct;48(4):1044-53. ABSTRACT COURTESY OF PUBMEDZABALA M, LASARTE JJ, PERRET C, SOLA J, BERRAONDO P, ALFARO M, LARREA E, PRIETO J, KRAMER MG. Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer. J Hepatol. 2007 Dec;47(6):807-15. Epub 2007 Oct 1. ABSTRACT COURTESY OF PUBMEDLUQUIN E, LARREA E, CIVEIRA MP, PRIETO J, ALDABE R. HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway. Antiviral Res. 2007 Nov;76(2):194-7. Epub 2007 Aug 6. ABSTRACT COURTESY OF PUBMEDROLLIER CS, PARANHOS-BACCALA G, VERSCHOOR EJ, VERSTREPEN BE, DREXHAGE JA, FAGROUCH Z, BERLAND JL, KOMURIAN-PRADEL F, DUVERGER B, HIMOUDI N, STAIB C, MEYR M, WHELAN M, WHELAN JA, ADAMS VC, LARREA E, RIEZU JI, LASARTE JJ, BARTOSCH B, COSSET FL, SPAAN WJ, DIEPOLDER HM, PAPE GR, SUTTER G, INCHAUSPE G, HEENEY JL. Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology 2007 Mar;45(3):602-13. ABSTRACT COURTESY OF PUBMEDLARREA E, RIEZU-BOJ JI, GIL-GUERRERO L, CASARES N, ALDABE R, SAROBE P, CIVEIRA MP, HEENEY JL, ROLLIER C, VERSTREPEN B, WAKITA T, BORRÁS-CUESTA F, LASARTE JJ, PRIETO J. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol. 2007 Apr;81(7):3662-6. Epub 2007 Jan 17. ABSTRACT COURTESY OF PUBMEDVILASCO M, LARREA E, VITOUR D, DABO S, BREIMAN A, REGNAULT B, RIEZU JI, EID P, PRIETO J, MEURS EF. The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers. Hepatology 2006 Dec;44(6):1635-47. ABSTRACT COURTESY OF PUBMEDGONZALEZ-ASEGUINOLAZA G, CRETTAZ J, OCHOA L, OTANO I, ALDABE R, PANEDA A. Gene therapy for viral hepatitis. Expert Opin Biol Ther. 2006 Dec;6(12):1263-78.
ABSTRACT COURTESY OF PUBMEDGUITART A, RIEZU-BOJ JI, ELIZALDE E, LARREA E, BERASAIN C, ALDABE R, CIVEIRA MP, PRIETO J. Hepatitis C virus infection of primary tupaia hepatocytes leads to selection of quasispecies variants, induction of interferon-stimulated genes and NF-kappaB nuclear translocation. J Gen Virol. 2005 Nov;86(Pt 11):3065-74. ABSTRACT COURTESY OF PUBMEDLARREA E, ALDABE R, MOLANO E, FERNANDEZ-RODRIGUEZ CM, AMETZAZURRA A, CIVEIRA MP, PRIETO J. Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies. Gut 2006 Aug;55(8):1188-96. Epub 2005 Aug 24. ABSTRACT COURTESY OF PUBMEDBERASAIN C, HEVIA H, FERNÁNDEZ-IRIGOYEN J, LARREA E, CABALLERÍA J, MATO JM, PRIETO J, CORRALES FJ, GARCÍA-TREVIJANO ER, AVILA MA. Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma. Biochim Biophys Acta. 2004 Nov 5;1690(3):276-84. ABSTRACT COURTESY OF PUBMEDLARREA E, ALDABE R, RIEZU-BOJ JI, GUITART A, CIVEIRA MP, PRIETO J, BAIXERAS E. IFN-alpha5 mediates stronger Tyk2-stat-dependent activation and higher
expression of 2',5'-oligoadenylate synthetase than IFN-alpha2 in liver
cells. J Interferon Cytokine Res. 2004 Aug;24(8):497-503. ABSTRACT COURTESY OF PUBMED |
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