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biomarkersSelected PublicationsMEDINA PP, ROMERO OA, KOHNO T, MONTUENGA LM, PIO R, YOKOTA J, SANCHEZ-CESPEDES M. Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.Hum Mutat. 2008 May;29(5):617-22. ABSTRACT COURTESY OF PUBMEDANTON MA, GOROSTIAGA D, GURUCEAGA E, SEGURA V, CARMONA-SAEZ P, PASCUAL-MONTANO A, PIO R, MONTUENGA LM, RUBIO A. SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays.Genome Biol. 2008;9(2):R46. ABSTRACT COURTESY OF PUBMEDCASTAÑO Z, VERGARA-IRIGARAY N, PAJARES MJ, MONTUENGA LM, PIO R. Expression of alpha CP-4 inhibits cell cycle progression and suppresses tumorigenicity of lung cancer cells. Int J Cancer. 2008 Apr 1;122(7):1512-20. ABSTRACT COURTESY OF PUBMEDZUDAIRE I, LOZANO MD, VAZQUEZ MF, PAJARES MJ, AGORRETA J, PIO R, ZULUETA JJ, YANKELEVITZ DF, HENSCHKE CI, MONTUENGA LM. Molecular characterization of small peripheral lung tumors based on the analysis of fine needle aspirates. Histol Histopathol. 2008 Jan;23(1):33-40. ABSTRACT COURTESY OF PUBMEDBLANCO D, VICENT S, FRAGA MF, FERNANDEZ-GARCIA I, FREIRE J, LUJAMBIO A, ESTELLER M, ORTIZ-DE-SOLORZANO C, PIO R, LECANDA F, MONTUENGA LM. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia. 2007 Oct;9(10):840-52. ABSTRACT COURTESY OF PUBMEDMONTUENGA LM, PIO R. Tumour-associated macrophages in nonsmall cell lung cancer: the role of interleukin-10.Eur Respir J. 2007 Oct;30(4):608-10. ROUZAUT A, IRIGOYEN M, MONTUENGA LM. Lymphangiogenesis and lung cancer. J Thorac Oncol. 2007 May;2(5):384-6. Review.
AJONA D, HSU YF, CORRALES L, MONTUENGA LM, PIO R. Down-regulation of human complement factor H
sensitizes non-small cell lung cancer cells to complement attack and
reduces in vivo tumor growth. J Immunol. 2007 May 1;178(9):5991-8. PAJARES MJ, EZPONDA T, CATENA R, CALVO A, PIO R, MONTUENGA LM. Alternative splicing: an emerging topic in molecular and clinical oncology. Lancet Oncol. 2007 Apr;8(4):349-57. Review. ABSTRACT COURTESY OF PUBMEDPAJARES MJ, ZUDAIRE I, LOZANO MD, AGORRETA J, BASTARRIKA G, TORRE W, REMÍREZ A, PIO R, ZULUETA JJ, MONTUENGA LM. Molecular profiling of computed tomography screen-detected lung nodules shows multiple malignant features. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):373-80. ABSTRACT COURTESY OF PUBMEDBASTARRIKA G, GARCÍA-VELLOSO MJ, LOZANO MD, MONTES U, TORRE W, SPITERI N, CAMPO A, SEIJO L, ALCAIDE AB, PUEYO J, CANO D, VIVAS I, COSÍN O, DOMÍNGUEZ P, SERRA P, RICHTER JA, MONTUENGA L, ZULUETA JJ. Early lung cancer detection using spiral computed tomography and positron emission tomography. Am J Respir Crit Care Med. 2005 Jun 15;171(12):1378-83. ABSTRACT COURTESY OF PUBMEDAGORRETA J, ZULUETA JJ, MONTUENGA LM, GARAYOA M. Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS. Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L536-45. ABSTRACT COURTESY OF PUBMEDZERBE LK, PINO I, PIO R, COSPER PF, DWYER-NIELD LD, MEYER AM, PORT JD, MONTUENGA LM, MALKINSON AM. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Mol Carcinog. 2004 Dec;41(4):187-96. ABSTRACT COURTESY OF PUBMEDAJONA D, CASTAÑO Z, GARAYOA M, ZUDAIRE E, PAJARES MJ, MARTINEZ A, CUTTITTA F, MONTUENGA LM, PIO R. Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement. Cancer Res. 2004 Sep 1;64(17):6310-8. ABSTRACT COURTESY OF PUBMEDABASOLO I, WANG Z, MONTUENGA LM, CALVO A. Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism. Biochem Biophys Res Commun. 2004 Sep 24;322(3):878-86. ABSTRACT COURTESY OF PUBMEDBLANCO D, VICENT S, ELIZEGI E, PINO I, FRAGA MF, ESTELLER M, SAFFIOTTI U, LECANDA F, MONTUENGA LM. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab Invest. 2004 Aug;84(8):999-1012. ABSTRACT COURTESY OF PUBMEDPIO R, ZUDAIRE I, PINO I, CASTAÑO Z, ZABALEGUI N, VICENT S, GARCIA-AMIGOT F, ODERO MD, LOZANO MD, GARCIA-FONCILLAS J, CALASANZ MJ, MONTUENGA LM. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. Cancer Res. 2004 Jun 15;64(12):4171-9. ABSTRACT COURTESY OF PUBMEDVICENT S, GARAYOA M, LÓPEZ-PICAZO JM, LOZANO MD, TOLEDO G, THUNNISSEN FB, MANZANO RG, MONTUENGA LM. Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients. Clin Cancer Res. 2004 Jun 1;10(11):3639-49. ABSTRACT COURTESY OF PUBMEDCARRETERO J, MEDINA PP, PIO R, MONTUENGA LM, SANCHEZ-CESPEDES M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene. 2004 May 13;23(22):4037-40. ABSTRACT COURTESY OF PUBMEDVICENT S, LÓPEZ-PICAZO JM, TOLEDO G, LOZANO MD, TORRE W, GARCIA-CORCHÓN C, QUERO C, SORIA JC, MARTÍN-ALGARRA S, MANZANO RG, MONTUENGA LM. ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. Br J Cancer. 2004 Mar 8;90(5):1047-52. ABSTRACT COURTESY OF PUBMEDJIMÉNEZ N, ABASOLO I, JONGSMA J, CALVO A, GARAYOA M, VAN DER KWAST TH, VAN STEENBRUGGE GJ, MONTUENGA LM. Androgen-independent expression of adrenomedullin and peptidylglycine alpha-amidating monooxygenase in human prostatic carcinoma. Mol Carcinog. 2003 Sep;38(1):14-24. ABSTRACT COURTESY OF PUBMEDPINO I, PÍO R, TOLEDO G, ZABALEGUI N, VICENT S, REY N, LOZANO MD, TORRE W, GARCÍA-FONCILLAS J, MONTUENGA LM. Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer. Lung Cancer. 2003 Aug;41(2):131-43. ABSTRACT COURTESY OF PUBMEDAGORRETA J, GARAYOA M, MONTUENGA LM, ZULUETA JJ. Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury. Am J Respir Crit Care Med. 2003 Aug 1;168(3):287-96. ABSTRACT COURTESY OF PUBMEDBASTARRIKA G, PUEYO JC, LOZANO MD, MONTUENGA L, ZULUETA JJ. Detección precoz del cáncer de pulmón por tomografía computarizada de baja dosis de radiación: resultados de una muestra de 150 individuos asintomáticos. Med Clin (Barc). 2003 Jun 14;121(2):41-7. ABSTRACT COURTESY OF PUBMEDABASOLO I, YANG L, HALEEM R, XIAO W, PIO R, CUTTITTA F, MONTUENGA LM, KOZLOWSKI JM, CALVO A, WANG Z. Overexpression of adrenomedullin gene markedly inhibits proliferation of PC3 prostate cancer cells in vitro and in vivo. Mol Cell Endocrinol. 2003 Jan 31;199(1-2):179-87. ABSTRACT COURTESY OF PUBMEDMONTUENGA LM, GUEMBE L, BURRELL MA, BODEGAS ME, CALVO A, SOLA JJ, SESMA P, VILLARO AC. The diffuse endocrine system: from embryogenesis to carcinogenesis. Prog Histochem Cytochem. 2003;38(2):155-272. Review. ABSTRACT COURTESY OF PUBMEDZUDAIRE I, PÍO R, MARTÍN-SUBERO I, LOZANO MD, BLANCO D, GARCÍA LÓPEZ JJ, ODERO DE DIOS MD, REY N, ZULUETA J, SIEBERT R, CALAZANZ MJ, MONTUENGA L. Desarrollo de la técnica de FICTION como nueva herramienta para el diagnóstico precoz de cáncer de pulmón. An Sist Sanit Navar. 2002 Sep-Dec;25(3):305-15. ABSTRACT COURTESY OF PUBMEDMARTÍNEZ A, VOS M, GUÉDEZ L, KAUR G, CHEN Z, GARAYOA M, PÍO R, MOODY T, STETLER-STEVENSON WG, KLEINMAN HK, CUTTITTA F. The effects of adrenomedullin overexpression in breast tumor cells. J Natl Cancer Inst. 2002 Aug 21;94(16):1226-37. ABSTRACT COURTESY OF PUBMEDFIELD JK, BRAMBILLA C, CAPORASO N, FLAHAULT A, HENSCHKE C, HERMAN J, HIRSCH F, LACHMANN P, LAM S, MAIER S, MONTUENGA LM, MULSHINE J, MURPHY M, PULLEN J, SPITZ M, TOCKMAN M, TYNDALE R, WISTUBA I, YOUNGSON J. Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations. Int J Oncol. 2002 Aug;21(2):369-73. Review. ABSTRACT COURTESY OF PUBMEDMANZANO RG, MONTUENGA LM, DAYTON M, DENT P, KINOSHITA I, VICENT S, GARDNER GJ, NGUYEN P, CHOI YH, TREPEL J, AUERSPERG N, BIRRER MJ. CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential. Oncogene. 2002 Jun 27;21(28):4435-47. ABSTRACT COURTESY OF PUBMEDCUTTITTA F, PÍO R, GARAYOA M, ZUDAIRE E, JULIÁN M, ELSASSER TH, MONTUENGA LM, MARTÍNEZ A. Adrenomedullin functions as an important tumor survival factor in human carcinogenesis. Microsc Res Tech. 2002 Apr 15;57(2):110-9. Review. ABSTRACT COURTESY OF PUBMEDZULUETA J, MONTUENGA LM. Detección precoz de cáncer de pulmón: el momento oportuno. Med Clin (Barc). 2002 Apr 6;118(12):460-2. ABSTRACT COURTESY OF PUBMEDELIZEGI E, PINO I, VICENT S, BLANCO D, SAFFIOTTI U, MONTUENGA LM. Hyperplasia of alveolar neuroendocrine cells in rat lung carcinogenesis by silica with selective expression of proadrenomedullin-derived peptides and amidating enzymes. Lab Invest. 2001 Dec;81(12):1627-38. ABSTRACT COURTESY OF PUBMEDJIMÉNEZ N, JONGSMA J, CALVO A, VAN DER KWAST TH, TRESTON AM, CUTTITTA F, SCHRÖDER FH, MONTUENGA LM, VAN STEENBRUGGE GJ. Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate. Int J Cancer. 2001 Oct 1;94(1):28-34. ABSTRACT COURTESY OF PUBMEDPIO R, MARTINEZ A, UNSWORTH EJ, KOWALAK JA, BENGOECHEA JA, ZIPFEL PF, ELSASSER TH, CUTTITTA F. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. J Biol Chem. 2001 Apr 13;276(15):12292-300. ABSTRACT COURTESY OF PUBMEDGARAYOA M, MARTÍNEZ A, LEE S, PÍO R, AN WG, NECKERS L, TREPEL J, MONTUENGA LM, RYAN H, JOHNSON R, GASSMANN M, CUTTITTA F. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol. 2000 Jun;14(6):848-62. ABSTRACT COURTESY OF PUBMEDMOODY TW, COY D, CUTTITTA F, MONTUENGA LM. Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells. Peptides. 2000 Jan;21(1):101-7. ABSTRACT COURTESY OF PUBMEDMONTUENGA LM, MULSHINE JL. New molecular strategies for early lung cancer detection. Cancer Invest. 2000;18(6):555-63. Review. ABSTRACT COURTESY OF PUBMED |
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