oncology

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GRADUATE STUDENT / INVESTIGADOR EN FORMACIÓN

A post-doctoral position is offered to work in two different but intertwined projects:

• Establish a mouse model in which model the process of cell transmigration across the lymphatic endothelium. Our recent research has been focused in the surface molecules that govern dendritic and lung cancer cell adhesion and transmigration through these vessels in in vitro models. Some molecules from the integrin family of cell surface molecules and their counterpart receptors in lymphatic endothelial cells had been pointed out. We are currently interested in studying it in an in vivo setting using confocal microscopy techniques.

• Recent publications form our group, have described how nicotine repetitive exposition induces a phenotypical change both in primary epithelial cells and in SCLC cells. This phenotype conferred them increased, resistance to chemotherapy, migration and adhesion to lymphatic endothelial cell monolayers. We have also demonstrated that nicotine treated SCLC cells form bigger and more vascularized tumors when injected subcutaneously. Now we are interested in modeling in a in vivo model how do these nicotine differentiated cells transmigrate through the lymphatic endothelium.

GRADUATE STUDENT / INVESTIGADOR EN FORMACIÓN

Following our recent publish papers on the role of chronic nicotine exposition in SCLC cell properties, a pre-doctoral position available to study whether nicotine differentiated cells are endowed with features of stem-like cells (see above).

Besides, our laboratory is deeply interested in the adaptation of the energetic metabolism of cancer cells when exposed to nicotine. We will invest our efforts in discriminate if there are changes in both aerobic and anaerobic metabolism focusing on ATP and NADP producing metabolic pathways. Our final goal is to target some of the enzymes involved in energy production by cancer cells in order to starve them and hamper its un-controlled growth.

RESEARCH ASSOCIATE / COLABORADOR DE INVESTIGACIÓN

A position is offered to work in a project aimed at the characterization of cell migratory processes in three-dimensional microdevices that resemble the native tissue environment where these processes occur. The candidate will be in charge of the development and will coordinate the development of 4D image analysis tools for the detection and tracking of cells on videos captured using spinning disk confocal microscopy (SDCM). The candidate must have proved experience on the analysis of fluorescence microscopy images, ideally LSCM or SDCM, and a Ph.D. degree in Engineering or Physics.

GRADUATE STUDENT / INVESTIGADOR EN FORMACIÓN

This position is for a predoctoral fellow, who will work in a project aimed at the characterization of the cardiac remodeling that occurs after a coronary infarct and its possible treatment using cell or tissue therapies (implants). The work will consist of the development of tools for the enhancement and quantification of ultrasound echocardiography images of animal models of the disease. The candidate must a basic training/degree on Engineering, Physics, Mathematics or related topic, and must have a Master of Science or Engineering degree in one of those areas, that is required to access the research phase of the doctorate.

GRADUATE STUDENT / INVESTIGADOR EN FORMACIÓN

This is a predoctoral fellowship position, to work in a project aimed at the characterization of the dynamics of telomere shortening in Lung cancer. The work will consist on the use of imaging techniques (time lapse microscopy, FMT) and molecular techniques to characterize, first in cell lines and later in animal models, the process of telomere shortening that occurs during cancer development. The candidate must have a basic training on Biology or Biochemistry, and hold a Masters of Science degree on one of those areas, to access the research phase of his/her doctorate.

RESEARCH ASSOCIATE / COLABORADOR DE INVESTIGACIÓN

A post-doctoral position is offered for working in a project related with the treatment of the myocardial infarction disease. We propose to develop a tissue engineering approach based on the use of biodegradable matrices combined or not with iPS or adipose stem cells (ADSC), with the goal of improving cell engraftment and functional effect in the animal infarct models. We will develop also microparticles able to release growth factors and cytokines involved in cardiac regeneration, with a controlled pattern. These studies will be performed in transgenic mice models and in order to transfer these results to a more clinically relevant model, in a pig model of myocardial infarction. Experience in molecular and cellular biology is required.

RESEARCH ASSOCIATE / COLABORADOR DE INVESTIGACIÓN

RESEARCH ASSOCIATE / COLABORADOR DE INVESTIGACIÓN

A posdoctoral position is available, starting September 2009 to work in a project related to the role of microRNAs in regulation of stem cells. The project involves the analysis of miRNA expression in iPS and other sources of stem cells and the role of certain microRNAS in self-renewal and differentiation with a particular emphasis in functional analysis. Epigenetic mechanisms of microRNA regulation are also part of the project A background and interest in molecular biology is required. (Cancer Res. 2009 May 15; 69:4443-53)

RESEARCH ASSOCIATE / COLABORADOR DE INVESTIGACIÓN

A posdoctoral position is available to work in a project related to the analysis of the role of epigenetics in Acute Lymphoblastic Leukemia. Studies involve the development of high throughput analysis of histone code in ALL cells, identification and isolation of leukemia initiating cells and in vivo studies in mice models of ALL. In vitro and in vivo testing of epigenetic drugs such as LBH589 and other HDACi is also part of the project. The candidate should have a strong background in molecular biology (Cancer Res. 2009 May 15; 69:4443-53, J Clin Oncol. 2009; 27:1316-22, Mol Cancer Res. 2008; 6:1830-40, Blood 2007; 109: 3462-9)

STAFF SCIENTIST / INVESTIGADOR

One post-doctoral position available immediately to attempt the isolation and functional characterization of the progenitor cells of origin of human mantle cell lymphoma (MCL). We are seeking a highly motivated person with a PhD in a relevant field and experience in stem cell biology, molecular biology, cancer biology, cell sorting and tissue culture. Familiarity with mouse hematopoiesis and/or with mouse models of cancer is also desirable. Interested candidates should submit a curriculum vitae and statement of interest to Dr. Jose A. Martínez-Climent (jamcliment@unav.es).